Background: Breast hypertrophy is associated with physical discomforts such as chronic inflamammary pruritus. Reduction mammoplasty has been shown to alleviate these symptoms, but local data from Kenya remains limited.

Objective: To evaluate the impact of reduction mammoplasty on pruritus relief.

Design: A prospective longitudinal cohort study.

Setting: Six surgical centers in Nairobi, Kenya.

Subjects/Participants: Sixty-nine patients undergoing reduction mammoplasty were assessed using a pruritus analogue scale preoperatively and at 2, 4, 6, and 12 weeks postoperatively. Data were analyzed using SPSS version 25. Changes in pruritus severity were evaluated using paired T-tests and repeated measures ANOVA, with a significance level of p ≤ 0.05.

Results: The participants ranged from 14 to 54 years, with juvenile gigantomastia being the most common cause (51%). There was a significant decrease in pruritus severity scores, from a preoperative mean of 2.81 to 0 at 12 weeks postoperatively (p < 0.001). A positive correlation was found between the amount of breast tissue resected and pruritus relief (p = 0.011).

Conclusion: Reduction mammoplasty significantly relieves inframammary pruritus in women with breast hypertrophy. These findings emphasize the therapeutic role of breast reduction surgery and support its recognition as a medically necessary procedure.